Chris Overall

University of British Columbia, Canada

Professor Chris Overall, University of British Columbia, Vancouver, is a fellow of the Royal Society of Canada, an Emeritus Canada Research Chair in Protease Proteomics and Systems Biology and a Senior Fellow of the Freiburg Institute of Advanced Studies, Albert-Ludwigs Universität Freiburg, Germany, where he is an Honorary Professor. His 303 papers are influential with an h-index of 103. He is best known for his development of N-terminomic methodology for the identification of protein N and C termini. One application of this is the discovery of protease substrates in vivo. He has applied these techniques to reveal new roles for proteases in immunity and disease, most recently in the COVID-19 pandemic, as well as molecular correctors to treat a MALT1 protease deficiency in a primary immunodeficiency. He Chairs the HUPO Chromosome-centric Human Proteome Project (C-HPP) and is the recipient of numerous awards e.g., Canadian National Proteomics Network Tony Pawson Award (2014); the Proteomass Scientific Society Award (2017); the 2018 international HUPO Discovery Award in Proteomics Sciences; and the 2022 Helmut Holzer Award.